When Blood Is Sent To The Lungs By The Heart Type 2 Diabetes – An Oral Drug That May Protect Against Heart Failure As Well As Lower Blood Sugar

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Type 2 Diabetes – An Oral Drug That May Protect Against Heart Failure As Well As Lower Blood Sugar

Dapagliflozin (Farxiga) is an SGLT2 inhibitor given in pill form for people diagnosed with type 2 diabetes and used with diet and exercise and sometimes other medications. It works by making the kidneys secrete more sugar in the urine. According to a study reported in October 2018 in the journal Cardiovascular Diabetes, This drug is also useful in treating heart failure, a complication of type 2 diabetes.

Heart failure occurs on the left side of the heart The lungs are unable to take blood and send it quickly to other parts of the body.

The heart is made up of muscle tissue that expands during stress. The inward growth of this muscle creates a small space to accommodate the blood flowing from the lungs. This causes the heart to fail, the lungs to fill with fluid from the blood.

An estimated 26 million people worldwide had heart failure in 2017. High blood sugar levels in type 2 diabetes damage the heart and blood vessels and can lead to high blood pressure. Blood pressure readings should be brought to a healthy level to reduce stress on the heart. A heart attack may not cause chest pain in people with type 2 diabetes because nerve damage reduces sensation. Therefore, prevention of heart disease is more important.

Researchers at Kobe University and several other research facilities in Japan looked at 58 people who had type 2 diabetes and who also had heart failure. Dapagliflozin at a dose of 5 mg/day was added to their usual regimen. After six months, the muscle tissue on the left side of the heart of the diabetics decreased in size. Brain natriuretic peptide (BNP), a protein secreted by heart cells in response to overstretching, was lower in participants whose BNP was too high. From this information, the researchers concluded that dapagliflozin may be useful in improving heart failure in people with type 2 diabetes.

Natriuretic peptide is effective in increasing potassium secretion in the kidneys, lowering blood pressure, and reducing blood volume in the heart and blood vessels.

Dapagliflozin is administered once daily, with or without food. It is prescribed as part of an overall treatment plan that includes diet and exercise. Side effects include…

  • urinary tract yeast infection,

  • stuffy nose sore throat

  • Frequent and excessive urination at night,

  • dizziness or light-headedness,

  • Ketoacidosis (check for ketones in the urine),

  • nausea and vomiting,

  • feeling very tired,

  • difficulty breathing,

  • Abdominal pain, and

  • Kidney injury.

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